In terms of methodology, natural IVF differs from conventional IVF. Contrary to natural IVF, which employs medicines to stimulate the growth of many follicles, conventional IVF focuses on the quality of the eggs retrieved and works in tandem with the woman's normal menstrual cycle (immature egg cells). Because the woman's health comes first with Natural IVF, there are less medications, fewer side effects, and shorter treatment times. Additionally, the focus of therapy is on eggs that will likely be of high quality and only require mild assistance to grow. However, it has drawbacks such as unexpectedly early ovulation or "LH surge," where the egg may not develop into a viable embryo, and a reduced success rate for pregnancies.
Conventional IVF has advantages such as the ability to identify and cure fertilization issues, test for genetic disorders, retain unused embryos for future use, and achieve a greater success rate. The overstimulation brought on by FSH injections puts individuals at a higher risk of developing Ovarian Hyperstimulation Syndrome (OHSS).